Thiol dependent intramolecular locking of Orai1 channels

Store-operated Ca(2+) entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and other pathologies. Reactive oxygen species interacting with cysteine residues can alter protein function. Pretreatment of...

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Detalles Bibliográficos
Autores principales: Alansary, Dalia, Schmidt, Barbara, Dörr, Kathrin, Bogeski, Ivan, Rieger, Heiko, Kless, Achim, Niemeyer, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022029/
https://www.ncbi.nlm.nih.gov/pubmed/27624281
http://dx.doi.org/10.1038/srep33347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022029/
https://www.ncbi.nlm.nih.gov/pubmed/27624281
http://dx.doi.org/10.1038/srep33347

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