Cargando…

Thiol dependent intramolecular locking of Orai1 channels

Store-operated Ca(2+) entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and other pathologies. Reactive oxygen species interacting with cysteine residues can alter protein function. Pretreatment of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alansary, Dalia, Schmidt, Barbara, Dörr, Kathrin, Bogeski, Ivan, Rieger, Heiko, Kless, Achim, Niemeyer, Barbara A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022029/ https://www.ncbi.nlm.nih.gov/pubmed/27624281 http://dx.doi.org/10.1038/srep33347

Ejemplares similares

Supra-Molecular Assemblies of ORAI1 at Rest Precede Local Accumulation into Puncta after Activation
por: Peckys, Diana B., et al.
Publicado: (2021)

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
por: Muik, Martin, et al.
Publicado: (2011)

A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP‐modulated NFAT signaling
por: Knapp, Mona L, et al.
Publicado: (2021)

CRACking the structure of Orai: New work reveals the intramolecular properties of a store-operated, calcium influx channel
por: Braun, Andrew P.
Publicado: (2013)

Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4(+) T-Cell Compartments
por: Merino-Wong, Maylin, et al.
Publicado: (2021)

Intramolecular Metal Exchange Reaction Promoted by Thiol Ligands
por: Li, Yangfeng, et al.
Publicado: (2018)

Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
por: Scanlan, Eoin M., et al.
Publicado: (2014)

Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
por: Yu, Changhui, et al.
Publicado: (2022)

Orai1 calcium channels in the vasculature
por: Beech, David J
Publicado: (2012)

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
por: Emrich, Scott M, et al.
Publicado: (2023)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

Toward a Model for Activation of Orai Channel
por: Dong, Hao, et al.
Publicado: (2019)

The remote allosteric control of Orai channel gating
por: Zhou, Yandong, et al.
Publicado: (2019)

Orai channel C-terminal peptides are key modulators of STlM-Orai coupling and calcium signal generation
por: Baraniak, James H., et al.
Publicado: (2021)

ORAI channels are critical for receptor-mediated endocytosis of albumin
por: Zeng, Bo, et al.
Publicado: (2017)

The exquisitely cooperative nature of Orai1 channel activation
por: Yeung, Priscilla See-Wai, et al.
Publicado: (2018)

Orai channels: key players in Ca(2+) homeostasis
por: Sallinger, Matthias, et al.
Publicado: (2020)

Orai1 Boosts SK3 Channel Activation
por: Tiffner, Adéla, et al.
Publicado: (2021)

Regulation of neuropathic pain by microglial Orai1 channels
por: Tsujikawa, Shogo, et al.
Publicado: (2023)

Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation
por: Tian, Yuan, et al.
Publicado: (2016)

Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta
por: Dynes, Joseph L., et al.
Publicado: (2020)

The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation
por: Sánchez-Collado, José, et al.
Publicado: (2021)

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
por: Yeung, Priscilla S-W, et al.
Publicado: (2023)

Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
por: Jardin, Isaac, et al.
Publicado: (2022)

Sphingomyelin, ORAI1 channels, and cellular Ca(2+) signaling
por: Hogan, Patrick G.
Publicado: (2015)

STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment
por: Frisch, Janina, et al.
Publicado: (2019)

Structures reveal opening of the store-operated calcium channel Orai
por: Hou, Xiaowei, et al.
Publicado: (2018)

Molecular understanding of calcium permeation through the open Orai channel
por: Liu, Xiaofen, et al.
Publicado: (2019)

Structural Insights into Ca(2+) Permeation through Orai Channels
por: Li, Yang, et al.
Publicado: (2021)

ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets
por: Rubaiy, Hussein N.
Publicado: (2023)

A STIM2 splice variant negatively regulates store-operated calcium entry
por: Miederer, Anna-Maria, et al.
Publicado: (2015)

SOAR and the polybasic STIM1 domains gate and regulate the Orai channels
por: Yuan, Joseph P., et al.
Publicado: (2009)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
por: Derler, Isabella, et al.
Publicado: (2013)

How Many Orai's Does It Take to Make a CRAC Channel?
por: Thompson, Jill L., et al.
Publicado: (2013)

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis
por: Szabó, Viktória, et al.
Publicado: (2023)

Crucial Role of Stromal Interaction Molecule-Activated TRPC-ORAI Channels in Vascular Remodeling and Pulmonary Hypertension Induced by Intermittent Hypoxia
por: Castillo-Galán, Sebastián, et al.
Publicado: (2022)

Selective recruitment of different Ca(2+)-dependent transcription factors by STIM1-Orai1 channel clusters
por: Lin, Yu-Ping, et al.
Publicado: (2019)

Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms
por: Chamlali, Mohamed, et al.
Publicado: (2021)

A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly
por: Weismiller, Hilary A., et al.
Publicado: (2021)

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure
por: Jardin, Isaac, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9nnposn3256trdce17fo6h2viu