Complement C5a induces PD-L1 expression and acts in synergy with LPS through Erk1/2 and JNK signaling pathways

Severe bacterial infection results in both uncontrolled inflammation and immune suppression in septic patients. Although there is ample evidence that complement activation provokes overwhelming pro-inflammatory responses, whether or not it plays a role in immune suppression in this case is unclear....

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Detalles Bibliográficos
Autores principales: An, Ling-Ling, Gorman, Jacob V., Stephens, Geoffrey, Swerdlow, Bonnie, Warrener, Paul, Bonnell, Jessica, Mustelin, Tomas, Fung, Michael, Kolbeck, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022031/
https://www.ncbi.nlm.nih.gov/pubmed/27624143
http://dx.doi.org/10.1038/srep33346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022031/
https://www.ncbi.nlm.nih.gov/pubmed/27624143
http://dx.doi.org/10.1038/srep33346

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