Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma()

BACKGROUND: Extensive cross talk exists between PI3K/Akt/mTOR and mitogen-activated protein kinase (MAPK) pathways, and both are upregulated in pancreatic ductal adenocarcinoma (PDAC). Our previous study suggested that epidermal growth factor receptor inhibitor erlotinib which acts upstream of these...

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Detalles Bibliográficos
Autores principales: Wong, Matthew H., Xue, Aiqun, Baxter, Robert C., Pavlakis, Nick, Smith, Ross C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022074/
https://www.ncbi.nlm.nih.gov/pubmed/27435925
http://dx.doi.org/10.1016/j.neo.2016.06.001

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