Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice

BACKGROUND/OBJECTIVES: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent studies have suggested an important role for inflammasome/caspase-1 in the development of NASH, but the potential therapeutic value of caspase-1 in...

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Detalles Bibliográficos
Autores principales: Morrison, M C, Mulder, P, Salic, K, Verheij, J, Liang, W, van Duyvenvoorde, W, Menke, A, Kooistra, T, Kleemann, R, Wielinga, P Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022108/
https://www.ncbi.nlm.nih.gov/pubmed/27121255
http://dx.doi.org/10.1038/ijo.2016.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022108/
https://www.ncbi.nlm.nih.gov/pubmed/27121255
http://dx.doi.org/10.1038/ijo.2016.74

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