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Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial
BACKGROUND: As adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used. In this study, the long-term efficacy and safety of metformin versus placebo in adolescents with obesity and insulin resista...
Autores principales: | van der Aa, M P, Elst, M A J, van de Garde, E M W, van Mil, E G A H, Knibbe, C A J, van der Vorst, M M J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022149/ https://www.ncbi.nlm.nih.gov/pubmed/27571249 http://dx.doi.org/10.1038/nutd.2016.37 |
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