Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model

Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) gene therapy applications. However, low gene marking was previously observed in gene therapy trials, suggesting that RIC might be insufficient for (i) opening niches for efficient engraftment and/or (ii) inducing imm...

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Detalles Bibliográficos
Autores principales: Uchida, Naoya, Weitzel, R Patrick, Shvygin, Anna, Skala, Luke P, Raines, Lydia, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Donahue, Robert E, Tisdale, John F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022796/
https://www.ncbi.nlm.nih.gov/pubmed/27652288
http://dx.doi.org/10.1038/mtm.2016.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022796/
https://www.ncbi.nlm.nih.gov/pubmed/27652288
http://dx.doi.org/10.1038/mtm.2016.59

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