Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells

Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects. In the present study, we found that a very low concentration of depsipeptide, an HDAC inhibitor, potentiated the antitumor activity of 5-fl...

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Detalles Bibliográficos
Autores principales: Okada, Kouji, Hakata, Shuko, Terashima, Jun, Gamou, Toshie, Habano, Wataru, Ozawa, Shogo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022900/
https://www.ncbi.nlm.nih.gov/pubmed/27509880
http://dx.doi.org/10.3892/or.2016.5008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022900/
https://www.ncbi.nlm.nih.gov/pubmed/27509880
http://dx.doi.org/10.3892/or.2016.5008

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