Valproic Acid Increases CD133 Positive Cells that Show Low Sensitivity to Cytostatics in Neuroblastoma

Valproic acid (VPA) is a well-known antiepileptic drug that exhibits antitumor activities through its action as a histone deacetylase inhibitor. CD133 is considered to be a cancer stem cell marker in several tumors including neuroblastoma. CD133 transcription is strictly regulated by epigenetic modi...

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Detalles Bibliográficos
Autores principales: Khalil, Mohamed Ashraf, Hraběta, Jan, Groh, Tomáš, Procházka, Pavel, Doktorová, Helena, Eckschlager, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023141/
https://www.ncbi.nlm.nih.gov/pubmed/27627801
http://dx.doi.org/10.1371/journal.pone.0162916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023141/
https://www.ncbi.nlm.nih.gov/pubmed/27627801
http://dx.doi.org/10.1371/journal.pone.0162916

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