Cargando…

Wdr1-Dependent Actin Reorganization in Platelet Activation

In resting platelets, the integrin αIIbβ3 is present in a low-affinity “bent” state. During platelet aggregation, intracytoplasmic signals induce conformational changes (inside-out signaling) that result in a “swung-out” conformation competent to bind ligands such as fibrinogen. The cytoskeleton pla...

Descripción completa

Detalles Bibliográficos
Autores principales: Dasgupta, Swapan K., Le, Anhquyen, Da, Qi, Cruz, Miguel, Rumbaut, Rolando E., Thiagarajan, Perumal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023164/
https://www.ncbi.nlm.nih.gov/pubmed/27627652
http://dx.doi.org/10.1371/journal.pone.0162897