Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

Dysregulation of Fibroblast Growth Factor Receptor (FGFR) signaling through amplifications, mutations, and gene fusions has been implicated in a broad array of cancers (e.g. liver, gastric, ovarian, endometrial, and bladder). ARQ 087 is a novel, ATP competitive, small molecule, multi-kinase inhibito...

Descripción completa

Detalles Bibliográficos
Autores principales: Hall, Terence G., Yu, Yi, Eathiraj, Sudharshan, Wang, Yunxia, Savage, Ronald E., Lapierre, Jean-Marc, Schwartz, Brian, Abbadessa, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023172/
https://www.ncbi.nlm.nih.gov/pubmed/27627808
http://dx.doi.org/10.1371/journal.pone.0162594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023172/
https://www.ncbi.nlm.nih.gov/pubmed/27627808
http://dx.doi.org/10.1371/journal.pone.0162594

Ejemplares similares