Understanding Heterogeneity in Clinical Cohorts Using Normative Models: Beyond Case-Control Studies

BACKGROUND: Despite many successes, the case-control approach is problematic in biomedical science. It introduces an artificial symmetry whereby all clinical groups (e.g., patients and control subjects) are assumed to be well defined, when biologically they are often highly heterogeneous. By definit...

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Detalles Bibliográficos
Autores principales: Marquand, Andre F., Rezek, Iead, Buitelaar, Jan, Beckmann, Christian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Archival Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023321/
https://www.ncbi.nlm.nih.gov/pubmed/26927419
http://dx.doi.org/10.1016/j.biopsych.2015.12.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023321/
https://www.ncbi.nlm.nih.gov/pubmed/26927419
http://dx.doi.org/10.1016/j.biopsych.2015.12.023

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