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Understanding Heterogeneity in Clinical Cohorts Using Normative Models: Beyond Case-Control Studies
BACKGROUND: Despite many successes, the case-control approach is problematic in biomedical science. It introduces an artificial symmetry whereby all clinical groups (e.g., patients and control subjects) are assumed to be well defined, when biologically they are often highly heterogeneous. By definit...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023321/ https://www.ncbi.nlm.nih.gov/pubmed/26927419 http://dx.doi.org/10.1016/j.biopsych.2015.12.023 |