Induction of Hematopoietic Microchimerism by Gene-Modified BMT Elicits Antigen-Specific B and T Cell Unresponsiveness toward Gene Therapy Products

BACKGROUND: Gene therapy is a promising treatment option for hemophilia and other protein deficiencies. However, immune responses against the transgene product represent an obstacle to safe and effective gene therapy, urging for the implementation of tolerization strategies. Induction of a hematopoi...

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Detalles Bibliográficos
Autores principales: Martinet, Jérémie, Bourdenet, Gwladys, Meliani, Amine, Jean, Laetitia, Adriouch, Sahil, Cohen, Jose L., Mingozzi, Federico, Boyer, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023671/
https://www.ncbi.nlm.nih.gov/pubmed/27695454
http://dx.doi.org/10.3389/fimmu.2016.00360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023671/
https://www.ncbi.nlm.nih.gov/pubmed/27695454
http://dx.doi.org/10.3389/fimmu.2016.00360

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