PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions

Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectiou...

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Detalles Bibliográficos
Autores principales: Barron, Rona M., King, Declan, Jeffrey, Martin, McGovern, Gillian, Agarwal, Sonya, Gill, Andrew C., Piccardo, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023723/
https://www.ncbi.nlm.nih.gov/pubmed/27376534
http://dx.doi.org/10.1007/s00401-016-1594-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023723/
https://www.ncbi.nlm.nih.gov/pubmed/27376534
http://dx.doi.org/10.1007/s00401-016-1594-5

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