Human-to-mouse prion-like propagation of mutant huntingtin protein

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder of the central nervous system (CNS) that is defined by a CAG expansion in exon 1 of the huntingtin gene leading to the production of mutant huntingtin (mHtt). To date, the disease pathophysiology has been thought to be pri...

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Detalles Bibliográficos
Autores principales: Jeon, Iksoo, Cicchetti, Francesca, Cisbani, Giulia, Lee, Suji, Li, Endan, Bae, Jiwoo, Lee, Nayeon, Li, Ling, Im, Wooseok, Kim, Manho, Kim, Hyun Sook, Oh, Seung-Hun, Kim, Tae-Aug, Ko, Jung Jae, Aubé, Benoit, Oueslati, Abid, Kim, Yun Joong, Song, Jihwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023734/
https://www.ncbi.nlm.nih.gov/pubmed/27221146
http://dx.doi.org/10.1007/s00401-016-1582-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023734/
https://www.ncbi.nlm.nih.gov/pubmed/27221146
http://dx.doi.org/10.1007/s00401-016-1582-9

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