A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

Cancer therapy targets malignant cells that are surrounded by a diverse complement of nonmalignant stromal cells. Therapy-induced damage of normal cells can alter the tumor microenvironment, causing cellular senescence and activating cancer-promoting inflammation. However, how these damage responses...

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Detalles Bibliográficos
Autores principales: Bent, Eric H., Gilbert, Luke A., Hemann, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024680/
https://www.ncbi.nlm.nih.gov/pubmed/27566778
http://dx.doi.org/10.1101/gad.284851.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024680/
https://www.ncbi.nlm.nih.gov/pubmed/27566778
http://dx.doi.org/10.1101/gad.284851.116

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