IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

Glutamine is an essential nutrient for cancer cell survival and proliferation. Enhanced utilization of glutamine often depletes its local supply, yet how cancer cells adapt to low glutamine conditions is largely unknown. Here, we report that IκB kinase β (IKKβ) is activated upon glutamine deprivatio...

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Detalles Bibliográficos
Autores principales: Reid, Michael A., Lowman, Xazmin H., Pan, Min, Tran, Thai Q., Warmoes, Marc O., Ishak Gabra, Mari B., Yang, Ying, Locasale, Jason W., Kong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024682/
https://www.ncbi.nlm.nih.gov/pubmed/27585591
http://dx.doi.org/10.1101/gad.287235.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024682/
https://www.ncbi.nlm.nih.gov/pubmed/27585591
http://dx.doi.org/10.1101/gad.287235.116

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