Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

[Image: see text] C-1027 is a chromoprotein enediyne antitumor antibiotic produced by Streptomyces globisporus. In the last step of biosynthesis of the (S)-3-chloro-5-hydroxy-β-tyrosine moiety of the C-1027 enediyne chromophore, SgcE6 and SgcC compose a two-component monooxygenase that hydroxylates...

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Detalles Bibliográficos
Autores principales: Chang, Chin-Yuan, Lohman, Jeremy R., Cao, Hongnan, Tan, Kemin, Rudolf, Jeffrey D., Ma, Ming, Xu, Weijun, Bingman, Craig A., Yennamalli, Ragothaman M., Bigelow, Lance, Babnigg, Gyorgy, Yan, Xiaohui, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024704/
https://www.ncbi.nlm.nih.gov/pubmed/27560143
http://dx.doi.org/10.1021/acs.biochem.6b00713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024704/
https://www.ncbi.nlm.nih.gov/pubmed/27560143
http://dx.doi.org/10.1021/acs.biochem.6b00713

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