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Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint
The Greatwall kinase/Mastl is an essential gene that indirectly inhibits the phosphatase activity toward mitotic Cdk1 substrates. Here we show that although Mastl knockout (Mastl(NULL)) MEFs enter mitosis, they progress through mitosis without completing cytokinesis despite the presence of misaligne...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025047/ https://www.ncbi.nlm.nih.gov/pubmed/27631493 http://dx.doi.org/10.1371/journal.pgen.1006310 |