Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

The Greatwall kinase/Mastl is an essential gene that indirectly inhibits the phosphatase activity toward mitotic Cdk1 substrates. Here we show that although Mastl knockout (Mastl(NULL)) MEFs enter mitosis, they progress through mitosis without completing cytokinesis despite the presence of misaligne...

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Detalles Bibliográficos
Autores principales: Diril, M. Kasim, Bisteau, Xavier, Kitagawa, Mayumi, Caldez, Matias J., Wee, Sheena, Gunaratne, Jayantha, Lee, Sang Hyun, Kaldis, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025047/
https://www.ncbi.nlm.nih.gov/pubmed/27631493
http://dx.doi.org/10.1371/journal.pgen.1006310

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