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miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington’s Disease Monkey Neural Cells

Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the expansion of polyglutamine (polyQ) tract that leads to motor, cognitive and psychiatric impairment. Currently there is no cure for HD. A transgenic HD nonhuman primate (HD-NHP) model was developed with progressive dev...

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Detalles Bibliográficos
Autores principales: Kunkanjanawan, Tanut, Carter, Richard L., Prucha, Melinda S., Yang, Jinjing, Parnpai, Rangsun, Chan, Anthony W. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025087/
https://www.ncbi.nlm.nih.gov/pubmed/27631085
http://dx.doi.org/10.1371/journal.pone.0162788