Cargando…

Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells

Melanoma is one common skin cancer. In the present study, the potential anti-melanoma activity by a liposomal C6 ceramide was tested in vitro. We showed that the liposomal C6 (ceramide) was cytotoxic and anti-proliferative against a panel of human melanoma cell lines (SK-Mel2, WM-266.4 and A-375 and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Fangzhen, Jin, Kai, Huang, Shenyu, Bao, Qi, Shao, Zheren, Hu, Xueqing, Ye, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025141/ https://www.ncbi.nlm.nih.gov/pubmed/27631768 http://dx.doi.org/10.1371/journal.pone.0159849

Ejemplares similares

VS-5584, a Novel PI3K-mTOR Dual Inhibitor, Inhibits Melanoma Cell Growth In Vitro and In Vivo
por: Shao, Zheren, et al.
Publicado: (2015)

Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide
por: Øverbye, Anders, et al.
Publicado: (2017)

C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
por: Sumanasekera, Chiranthani, et al.
Publicado: (2012)

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH
por: Zanieri, Francesca, et al.
Publicado: (2020)

Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent
por: Lv, Huiqing, et al.
Publicado: (2016)

A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide
por: Van Overloop, Helena, et al.
Publicado: (2012)

Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations
por: Eder, Sascha, et al.
Publicado: (2022)

Complexation of C6-Ceramide with Cholesteryl Phosphocholine – A Potent Solvent-Free Ceramide Delivery Formulation for Cells in Culture
por: Sukumaran, Pramod, et al.
Publicado: (2013)

Structure and Interaction of Ceramide-Containing Liposomes with Gold Nanoparticles as Characterized by SERS and Cryo-EM
por: Feng, Yiqing, et al.
Publicado: (2022)

A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast
por: Woodacre, Alexandra, et al.
Publicado: (2013)

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo
por: Bharath, Leena P., et al.
Publicado: (2015)

Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)
por: Samaha, Doaa, et al.
Publicado: (2020)

C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway
por: Liu, Liping, et al.
Publicado: (2020)

C6-Ceramide Nanoliposomes Target the Warburg Effect in Chronic Lymphocytic Leukemia
por: Ryland, Lindsay K., et al.
Publicado: (2013)

Cell-intrinsic ceramides determine T cell function during melanoma progression
por: Hose, Matthias, et al.
Publicado: (2022)

AICAR inhibits ceramide biosynthesis in skeletal muscle
por: Erickson, Katherine A, et al.
Publicado: (2012)

Ceramide and ceramide 1-phosphate in health and disease
por: Arana, Lide, et al.
Publicado: (2010)

Intracellular trafficking of ceramide by ceramide transfer protein
por: Hanada, Kentaro
Publicado: (2010)

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6
por: Schüll, S, et al.
Publicado: (2015)

Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif
por: Kim, Jiyoon, et al.
Publicado: (2022)

Coupling In vitro and In vivo Paradigm Reveals a Dose Dependent Inhibition of Angiogenesis Followed by Initiation of Autophagy by C6-Ceramide
por: Bansode, Rishipal R., et al.
Publicado: (2011)

Exercise Promotes Pro-Apoptotic Ceramide Signaling in a Mouse Melanoma Model
por: Lee, Jonghae, et al.
Publicado: (2022)

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
por: Wang, Zheng, et al.
Publicado: (2017)

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution
por: Holmes, Roger S., et al.
Publicado: (2018)

Azido-Ceramides, a Tool to Analyse SARS-CoV-2 Replication and Inhibition—SARS-CoV-2 Is Inhibited by Ceramides
por: Brenner, Daniela, et al.
Publicado: (2023)

Lentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer
por: Qi, Yuying, et al.
Publicado: (2015)

C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma
por: Wilhelm, Raphael, et al.
Publicado: (2021)

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach
por: Raichur, Suryaprakash, et al.
Publicado: (2019)

Ceramide Inhibits Antigen Uptake and Presentation by Dendritic Cells
por: Sallusto, Federica, et al.
Publicado: (1996)

Erratum: Lentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer
por: Qi, Yuying, et al.
Publicado: (2016)

STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia
por: Doshi, Ushma A, et al.
Publicado: (2017)

Remodeling tumor microenvironment by liposomal codelivery of DMXAA and simvastatin inhibits malignant melanoma progression
por: Rauca, Valentin-Florian, et al.
Publicado: (2021)

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice
por: Li, Guangfu, et al.
Publicado: (2018)

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody
por: Jiang, Xue, et al.
Publicado: (2019)

CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease
por: Wang, Xiangyu, et al.
Publicado: (2023)

Ceramide in the prostate
por: Dent, Paul
Publicado: (2013)

Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities
por: Lai, Michele, et al.
Publicado: (2019)

Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria
por: Becam, Jérôme, et al.
Publicado: (2017)

The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines
por: Field, Bianca C., et al.
Publicado: (2020)

Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification
por: Hilvo, Mika, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7dd0b6t671s9vikuu4m45of8kj