Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma

In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutations can be deleterious to individual protein funct...

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Detalles Bibliográficos
Autores principales: Budzinska, Magdalena A., Tu, Thomas, d’Avigdor, William M. H., McCaughan, Geoffrey W., Luciani, Fabio, Shackel, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025244/
https://www.ncbi.nlm.nih.gov/pubmed/27631787
http://dx.doi.org/10.1371/journal.pone.0162586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025244/
https://www.ncbi.nlm.nih.gov/pubmed/27631787
http://dx.doi.org/10.1371/journal.pone.0162586

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