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Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma
In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutations can be deleterious to individual protein funct...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025244/ https://www.ncbi.nlm.nih.gov/pubmed/27631787 http://dx.doi.org/10.1371/journal.pone.0162586 |