A Genetic Screen Identifies a Critical Role for the WDR81‐WDR91 Complex in the Trafficking and Degradation of Tetherin

Tetherin (BST2/CD317) is a viral restriction factor that anchors enveloped viruses to host cells and limits viral spread. The HIV‐1 Vpu accessory protein counteracts tetherin by decreasing its cell surface expression and targeting it for ubiquitin‐dependent endolysosomal degradation. Although the Vp...

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Detalles Bibliográficos
Autores principales: Rapiteanu, Radu, Davis, Luther J., Williamson, James C., Timms, Richard T., Paul Luzio, J., Lehner, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025723/
https://www.ncbi.nlm.nih.gov/pubmed/27126989
http://dx.doi.org/10.1111/tra.12409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025723/
https://www.ncbi.nlm.nih.gov/pubmed/27126989
http://dx.doi.org/10.1111/tra.12409

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