(13)C magnetic resonance spectroscopy measurements with hyperpolarized [1‐(13)C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

PURPOSE: Dissolution dynamic nuclear polarization can increase the sensitivity of the (13)C magnetic resonance spectroscopy experiment by at least four orders of magnitude and offers a novel approach to the development of MRI gene reporters based on enzymes that metabolize (13)C‐labeled tracers. We...

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Detalles Bibliográficos
Autores principales: Dzien, Piotr, Tee, Sui‐Seng, Kettunen, Mikko I., Lyons, Scott K., Larkin, Timothy J., Timm, Kerstin N., Hu, De‐En, Wright, Alan, Rodrigues, Tiago B., Serrao, Eva M., Marco‐Rius, Irene, Mannion, Elizabeth, D'Santos, Paula, Kennedy, Brett W. C., Brindle, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Preclinical and Clinical Spectroscopy—Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025726/
https://www.ncbi.nlm.nih.gov/pubmed/26388418
http://dx.doi.org/10.1002/mrm.25879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025726/
https://www.ncbi.nlm.nih.gov/pubmed/26388418
http://dx.doi.org/10.1002/mrm.25879

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