Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength of GR-dependent activation of nearby genes. Our st...

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Detalles Bibliográficos
Autores principales: Schöne, Stefanie, Jurk, Marcel, Helabad, Mahdi Bagherpoor, Dror, Iris, Lebars, Isabelle, Kieffer, Bruno, Imhof, Petra, Rohs, Remo, Vingron, Martin, Thomas-Chollier, Morgane, Meijsing, Sebastiaan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025757/
https://www.ncbi.nlm.nih.gov/pubmed/27581526
http://dx.doi.org/10.1038/ncomms12621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025757/
https://www.ncbi.nlm.nih.gov/pubmed/27581526
http://dx.doi.org/10.1038/ncomms12621

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