Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

Gut microbiota promotes atherosclerosis, and vascular endothelial dysfunction, signalled by impaired endothelium-dependent vasorelaxation, is an early marker of atherosclerosis. Here we show that vascular microRNA-204 (miR-204) expression is remotely regulated by the microbiome, and impairs endothel...

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Detalles Bibliográficos
Autores principales: Vikram, Ajit, Kim, Young-Rae, Kumar, Santosh, Li, Qiuxia, Kassan, Modar, Jacobs, Julia S., Irani, Kaikobad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025761/
https://www.ncbi.nlm.nih.gov/pubmed/27586459
http://dx.doi.org/10.1038/ncomms12565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025761/
https://www.ncbi.nlm.nih.gov/pubmed/27586459
http://dx.doi.org/10.1038/ncomms12565

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