Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax

Multiple myeloma (MM) is a plasma cell malignancy that is largely incurable due to development of resistance to therapy-elicited cell death. Nutrients are intricately connected to maintenance of cellular viability in part by inhibition of apoptosis. We were interested to determine if examination of...

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Detalles Bibliográficos
Autores principales: Bajpai, R, Matulis, SM, Wei, C, Nooka, AK, Von Hollen, HE, Lonial, S, Boise, LH, Shanmugam, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025767/
https://www.ncbi.nlm.nih.gov/pubmed/26640142
http://dx.doi.org/10.1038/onc.2015.464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025767/
https://www.ncbi.nlm.nih.gov/pubmed/26640142
http://dx.doi.org/10.1038/onc.2015.464

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