Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development of copper complexes endowed with proteasome inhibition features has emerged as a promising anticancer strategy. However, limited information i...

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Detalles Bibliográficos
Autores principales: Santoro, Anna Maria, Monaco, Irene, Attanasio, Francesco, Lanza, Valeria, Pappalardo, Giuseppe, Tomasello, Marianna Flora, Cunsolo, Alessandra, Rizzarelli, Enrico, De Luigi, Ada, Salmona, Mario, Milardi, Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025780/
https://www.ncbi.nlm.nih.gov/pubmed/27633879
http://dx.doi.org/10.1038/srep33444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025780/
https://www.ncbi.nlm.nih.gov/pubmed/27633879
http://dx.doi.org/10.1038/srep33444

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