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APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway

The ubiquitin (Ub) ligase anaphase promoting complex/cyclosome (APC/C) and the tumour suppressor retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G(1)-phase of the cell cycle whereas pRB keeps a check on proliferation by inhibiting tr...

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Detalles Bibliográficos
Autores principales: Ramanujan, Ajeena, Tiwari, Swati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025812/
https://www.ncbi.nlm.nih.gov/pubmed/27402801
http://dx.doi.org/10.1042/BSR20160152