Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins

The ubiquitin-like protein ISG15 and its conjugation to proteins (ISGylation) are strongly induced by type I interferon. Influenza B virus encodes non-structural protein 1 (NS1B) that binds human ISG15 and provides an appropriate model for determining how ISGylation affects virus replication in huma...

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Detalles Bibliográficos
Autores principales: Zhao, Chen, Sridharan, Haripriya, Chen, Ran, Baker, Darren P., Wang, Shanshan, Krug, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025834/
https://www.ncbi.nlm.nih.gov/pubmed/27587337
http://dx.doi.org/10.1038/ncomms12754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025834/
https://www.ncbi.nlm.nih.gov/pubmed/27587337
http://dx.doi.org/10.1038/ncomms12754

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