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Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin

Peroxiredoxin is an abundant peroxidase, but its non-peroxidase function is also important. In this study, we discovered that Tsa1, a major peroxiredoxin of budding yeast cells, is required for the efficient flux of gluconeogenesis. We found that the suppression of pyruvate kinase (Pyk1) via the int...

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Detalles Bibliográficos
Autores principales: Irokawa, Hayato, Tachibana, Tsuyoshi, Watanabe, Toshihiko, Matsuyama, Yuka, Motohashi, Hozumi, Ogasawara, Ayako, Iwai, Kenta, Naganuma, Akira, Kuge, Shusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025857/
https://www.ncbi.nlm.nih.gov/pubmed/27634403
http://dx.doi.org/10.1038/srep33536