Biochemical and structural characterization of the interface mediating interaction between the influenza A virus non-structural protein-1 and a monoclonal antibody

We have previously shown that a non-structural protein 1 (NS1)-binding monoclonal antibody, termed as 2H6, can significantly reduce influenza A virus (IAV) replication when expressed intracellularly. In this study, we further showed that 2H6 binds stronger to the NS1 of H5N1 than A/Puerto Rico/8/193...

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Detalles Bibliográficos
Autores principales: Wu, Jianping, Mok, Chee-Keng, Chow, Vincent Tak Kwong, Yuan, Y. Adam, Tan, Yee-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025888/
https://www.ncbi.nlm.nih.gov/pubmed/27633136
http://dx.doi.org/10.1038/srep33382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025888/
https://www.ncbi.nlm.nih.gov/pubmed/27633136
http://dx.doi.org/10.1038/srep33382

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