Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

The cyclo‐dipeptide substrates of the essential M. tuberculosis (Mtb) enzyme CYP121 were deconstructed into their component fragments and screened against the enzyme. A number of hits were identified, one of which exhibited an unexpected inhibitor‐like binding mode. The inhibitory pharmacophore was...

Descripción completa

Detalles Bibliográficos
Autores principales: Kavanagh, Madeline E., Gray, Janine L., Gilbert, Sophie H., Coyne, Anthony G., McLean, Kirsty J., Davis, Holly J., Munro, Andrew W., Abell, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026067/
https://www.ncbi.nlm.nih.gov/pubmed/27432475
http://dx.doi.org/10.1002/cmdc.201600248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026067/
https://www.ncbi.nlm.nih.gov/pubmed/27432475
http://dx.doi.org/10.1002/cmdc.201600248

Ejemplares similares