Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein–protein interactions by the MDM2 ligand nutlin‐3

Drugs targeting MDM2's hydrophobic pocket activate p53. However, these agents act allosterically and have agonist effects on MDM2's protein interaction landscape. Dominant p53‐independent MDM2‐drug responsive‐binding proteins have not been stratified. We used as a variable the differential...

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Detalles Bibliográficos
Autores principales: Way, Luke, Faktor, Jakub, Dvorakova, Petra, Nicholson, Judith, Vojtesek, Borek, Graham, Duncan, Ball, Kathryn L., Hupp, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026170/
https://www.ncbi.nlm.nih.gov/pubmed/27273042
http://dx.doi.org/10.1002/pmic.201500501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026170/
https://www.ncbi.nlm.nih.gov/pubmed/27273042
http://dx.doi.org/10.1002/pmic.201500501

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