Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis‐driven selection rules

Seamless phase II/III clinical trials offer an efficient way to select an experimental treatment and perform confirmatory analysis within a single trial. However, combining the data from both stages in the final analysis can induce bias into the estimates of treatment effects. Methods for bias adjus...

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Detalles Bibliográficos
Autores principales: Robertson, David S., Prevost, A. Toby, Bowden, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026174/
https://www.ncbi.nlm.nih.gov/pubmed/27103068
http://dx.doi.org/10.1002/sim.6974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026174/
https://www.ncbi.nlm.nih.gov/pubmed/27103068
http://dx.doi.org/10.1002/sim.6974

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