A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1 cells show reduced ubiquitination of multiple RPs...

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Detalles Bibliográficos
Autores principales: Sung, Min-Kyung, Porras-Yakushi, Tanya R, Reitsma, Justin M, Huber, Ferdinand M, Sweredoski, Michael J, Hoelz, André, Hess, Sonja, Deshaies, Raymond J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026473/
https://www.ncbi.nlm.nih.gov/pubmed/27552055
http://dx.doi.org/10.7554/eLife.19105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026473/
https://www.ncbi.nlm.nih.gov/pubmed/27552055
http://dx.doi.org/10.7554/eLife.19105

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