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A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1 cells show reduced ubiquitination of multiple RPs...

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Detalles Bibliográficos
Autores principales:	Sung, Min-Kyung, Porras-Yakushi, Tanya R, Reitsma, Justin M, Huber, Ferdinand M, Sweredoski, Michael J, Hoelz, André, Hess, Sonja, Deshaies, Raymond J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026473/ https://www.ncbi.nlm.nih.gov/pubmed/27552055 http://dx.doi.org/10.7554/eLife.19105

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