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Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers

BACKGROUND: Little is known regarding the etiology and genomic underpinnings of Oral Tongue Squamous Cell Carcinoma (OTSCC) in patients who lack traditional risk factors, yet the incidence is increasing. In particular, the rate, and role, of TP53 mutations in this cohort has been heavily debated in...

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Detalles Bibliográficos
Autores principales: Faden, Daniel L., Arron, Sarah T., Heaton, Chase M., DeRisi, Joseph, South, Andrew P., Wang, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027093/
https://www.ncbi.nlm.nih.gov/pubmed/27640185
http://dx.doi.org/10.1186/s40463-016-0160-4