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Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells

BACKGROUND: The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-mediated RNAa is an evolutionarily conserved mechanism. Previous studies hav...

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Detalles Bibliográficos
Autores principales: Wu, Huan-Lei, Li, Sen-Mao, Hu, Jia, Yu, Xiao, Xu, Hua, Chen, Zhong, Ye, Zhang-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027115/
https://www.ncbi.nlm.nih.gov/pubmed/27639690
http://dx.doi.org/10.1186/s13046-016-0423-y