Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins

Optineurin is an important autophagy receptor involved in several selective autophagy processes, during which its function is regulated by TBK1. Mutations of optineurin and TBK1 are both associated with neurodegenerative diseases. However, the mechanistic basis underlying the specific interaction be...

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Detalles Bibliográficos
Autores principales: Li, Faxiang, Xie, Xingqiao, Wang, Yingli, Liu, Jianping, Cheng, Xiaofang, Guo, Yujiao, Gong, Yukang, Hu, Shichen, Pan, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027247/
https://www.ncbi.nlm.nih.gov/pubmed/27620379
http://dx.doi.org/10.1038/ncomms12708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027247/
https://www.ncbi.nlm.nih.gov/pubmed/27620379
http://dx.doi.org/10.1038/ncomms12708

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