A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

Understanding the natural evolution and structural changes involved in broadly neutralizing antibody (bnAb) development holds great promise for improving the design of prophylactic influenza vaccines. Here we report an haemagglutinin (HA) stem-directed bnAb, 3I14, isolated from human memory B cells,...

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Detalles Bibliográficos
Autores principales: Fu, Ying, Zhang, Zhen, Sheehan, Jared, Avnir, Yuval, Ridenour, Callie, Sachnik, Thomas, Sun, Jiusong, Hossain, M. Jaber, Chen, Li-Mei, Zhu, Quan, Donis, Ruben O., Marasco, Wayne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027281/
https://www.ncbi.nlm.nih.gov/pubmed/27619409
http://dx.doi.org/10.1038/ncomms12780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027281/
https://www.ncbi.nlm.nih.gov/pubmed/27619409
http://dx.doi.org/10.1038/ncomms12780

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