A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells

Overexpression of AURKA is a major hallmark of epithelial cancers. It encodes the multifunctional serine/threonine kinase aurora A, which is activated at metaphase and is required for cell cycle progression; assessing its activation in living cells is mandatory for next-generation drug design. We de...

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Detalles Bibliográficos
Autores principales: Bertolin, Giulia, Sizaire, Florian, Herbomel, Gaëtan, Reboutier, David, Prigent, Claude, Tramier, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027284/
https://www.ncbi.nlm.nih.gov/pubmed/27624869
http://dx.doi.org/10.1038/ncomms12674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027284/
https://www.ncbi.nlm.nih.gov/pubmed/27624869
http://dx.doi.org/10.1038/ncomms12674

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