Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

Eukaryotic elongation factor EEF1A1 is induced by oxidative and ER stress, and contributes to subsequent cell death in many cell types, including hepatocytes. We recently showed that blocking the protein synthesis activity of EEF1A1 with the peptide inhibitor, didemnin B, decreases saturated fatty a...

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Detalles Bibliográficos
Autores principales: Hetherington, Alexandra M., Sawyez, Cynthia G., Sutherland, Brian G., Robson, Debra L., Arya, Rigya, Kelly, Karen, Jacobs, René L., Borradaile, Nica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027364/
https://www.ncbi.nlm.nih.gov/pubmed/27613825
http://dx.doi.org/10.14814/phy2.12963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027364/
https://www.ncbi.nlm.nih.gov/pubmed/27613825
http://dx.doi.org/10.14814/phy2.12963

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