The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers

Various forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful against a subset of ALK(+) tumours, clinical resistance to this drug has been well recognized and the mechanism of this phen...

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Detalles Bibliográficos
Autores principales: Alshareef, Abdulraheem, Zhang, Hai-Feng, Huang, Yung-Hsing, Wu, Chengsheng, Zhang, Jing Dong, Wang, Peng, El-Sehemy, Ahmed, Fares, Mohamed, Lai, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027386/
https://www.ncbi.nlm.nih.gov/pubmed/27641368
http://dx.doi.org/10.1038/srep33710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027386/
https://www.ncbi.nlm.nih.gov/pubmed/27641368
http://dx.doi.org/10.1038/srep33710

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