Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment

Chromosome translocations are hallmark of cancer and of radiation-induced cell killing, reflecting joining of incongruent DNA-ends that alter the genome. Translocation-formation requires DNA end-joining mechanisms and incompletely characterized, permissive chromatin conditions. We show that chromati...

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Detalles Bibliográficos
Autores principales: Schipler, Agnes, Mladenova, Veronika, Soni, Aashish, Nikolov, Vladimir, Saha, Janapriya, Mladenov, Emil, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027484/
https://www.ncbi.nlm.nih.gov/pubmed/27257076
http://dx.doi.org/10.1093/nar/gkw487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027484/
https://www.ncbi.nlm.nih.gov/pubmed/27257076
http://dx.doi.org/10.1093/nar/gkw487

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