Cargando…

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment

Chromosome translocations are hallmark of cancer and of radiation-induced cell killing, reflecting joining of incongruent DNA-ends that alter the genome. Translocation-formation requires DNA end-joining mechanisms and incompletely characterized, permissive chromatin conditions. We show that chromati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schipler, Agnes, Mladenova, Veronika, Soni, Aashish, Nikolov, Vladimir, Saha, Janapriya, Mladenov, Emil, Iliakis, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027484/ https://www.ncbi.nlm.nih.gov/pubmed/27257076 http://dx.doi.org/10.1093/nar/gkw487

Ejemplares similares

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
por: Mladenov, Emil, et al.
Publicado: (2020)

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining
por: Soni, Aashish, et al.
Publicado: (2014)

Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining
por: Liang, Zhuobin, et al.
Publicado: (2016)

Acetylation of 53BP1 dictates the DNA double strand break repair pathway
por: Guo, Xiang, et al.
Publicado: (2018)

Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways
por: Wang, Minli, et al.
Publicado: (2013)

RecBCD coordinates repair of two ends at a DNA double-strand break, preventing aberrant chromosome amplification
por: White, Martin A, et al.
Publicado: (2018)

HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
por: Zhang, Zhen, et al.
Publicado: (2023)

Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair
por: Singh, Satyendra K., et al.
Publicado: (2011)

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase
por: Lee, Kyung-Jong, et al.
Publicado: (2016)

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
por: Asaithamby, Aroumougame, et al.
Publicado: (2011)

Disease-associated DNA2 nuclease–helicase protects cells from lethal chromosome under-replication
por: Falquet, Benoît, et al.
Publicado: (2020)

A perfect palindrome in the Escherichia coli chromosome forms DNA hairpins on both leading- and lagging-strands
por: Azeroglu, Benura, et al.
Publicado: (2014)

ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination
por: Lee, Doohyung, et al.
Publicado: (2022)

The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin
por: Winterhalter, Charles, et al.
Publicado: (2023)

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1
por: Watanabe, Kenji, et al.
Publicado: (2009)

Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection
por: Klebanov-Akopyan, Olga, et al.
Publicado: (2018)

Role for DNA double strand end-resection activity of RecBCD in control of aberrant chromosomal replication initiation in Escherichia coli
por: Goswami, Sayantan, et al.
Publicado: (2022)

Widely spaced and divergent inverted repeats become a potent source of chromosomal rearrangements in long single-stranded DNA regions
por: Ait Saada, Anissia, et al.
Publicado: (2023)

A novel nucleoid-associated protein coordinates chromosome replication and chromosome partition
por: Taylor, James A., et al.
Publicado: (2017)

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection
por: Fouquin, Alexis, et al.
Publicado: (2017)

RNF8 has both KU-dependent and independent roles in chromosomal break repair
por: Tsai, Linda Jillianne, et al.
Publicado: (2020)

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction
por: Oh, Sehyun, et al.
Publicado: (2013)

Acentric chromosome ends are prone to fusion with functional chromosome ends through a homology-directed rearrangement
por: Ohno, Yuko, et al.
Publicado: (2016)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements
por: Elango, Rajula, et al.
Publicado: (2019)

Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors
por: Sima, Jiao, et al.
Publicado: (2018)

Cassette recruitment in the chromosomal Integron of Vibrio cholerae
por: Vit, Claire, et al.
Publicado: (2021)

Mechanistic analysis of Xenopus EXO1's function in 5′-strand resection at DNA double-strand breaks
por: Liao, Shuren, et al.
Publicado: (2011)

Double-strand break toxicity is chromatin context independent
por: Friskes, Anoek, et al.
Publicado: (2022)

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
por: Paliwal, Shreya, et al.
Publicado: (2014)

Vibrio cholerae chromosome 2 copy number is controlled by the methylation-independent binding of its monomeric initiator to the chromosome 1 crtS site
por: de Lemos Martins, Francisco, et al.
Publicado: (2018)

Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer
por: Iliakis, George, et al.
Publicado: (2019)

DNA catenation maintains structure of human metaphase chromosomes
por: Bauer, David L. V., et al.
Publicado: (2012)

Nuclear import of Cdc13 limits chromosomal capping
por: Mersaoui, Sofiane Y, et al.
Publicado: (2018)

PRL-3 promotes telomere deprotection and chromosomal instability
por: Lian, Shenyi, et al.
Publicado: (2017)

The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm
por: Ayuda-Durán, Pilar, et al.
Publicado: (2014)

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template
por: Metzger, Michael J., et al.
Publicado: (2011)

ARF induction in response to DNA strand breaks is regulated by PARP1
por: Orlando, Giulia, et al.
Publicado: (2014)

A double-strand break can trigger immunoglobulin gene conversion
por: Bastianello, Giulia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tmg8762mq1pa415nm13t69bc5k