Phosphorylation of Ku70 subunit by cell cycle kinases modulates the replication related function of Ku heterodimer

The Ku protein, a heterodimer of Ku70 and Ku80, binds to chromosomal replication origins maximally at G1-phase and plays an essential role in assembly of origin recognition complex. However, the mechanism regulating such a critical periodic activity of Ku remained unknown. Here, we establish human K...

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Detalles Bibliográficos
Autores principales: Mukherjee, Soumita, Chakraborty, Prabal, Saha, Partha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027504/
https://www.ncbi.nlm.nih.gov/pubmed/27402161
http://dx.doi.org/10.1093/nar/gkw622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027504/
https://www.ncbi.nlm.nih.gov/pubmed/27402161
http://dx.doi.org/10.1093/nar/gkw622

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